Researchers tested a special probiotic called AntiAGE-Biom to see if it could help people with type 2 diabetes control their blood sugar and improve their body composition. In a 3-month study with 40 participants, the probiotic didn’t significantly lower blood sugar levels, but it did help reduce body fat and increase muscle mass, especially in men. While these results are encouraging, the study was small, so more research is needed before doctors might recommend it as a standard treatment.

The Quick Take

  • What they studied: Whether a probiotic supplement (AntiAGE-Biom) could help people with type 2 diabetes improve their blood sugar control and body composition over 3 months
  • Who participated: 40 adults with type 2 diabetes who had reasonably controlled blood sugar levels. Half received the probiotic and half received a placebo (fake pill) that looked identical
  • Key finding: The probiotic didn’t significantly lower blood sugar levels as hoped, but it did help reduce body fat percentage and increase muscle mass in men and in people with higher starting blood sugar levels
  • What it means for you: This probiotic may help improve body composition in people with type 2 diabetes, but it shouldn’t replace your current diabetes medications. More research with larger groups is needed before it becomes a standard recommendation

The Research Details

This was a randomized controlled trial, which is considered one of the best ways to test if something actually works. The researchers randomly assigned 40 people with type 2 diabetes into two equal groups: one group took the AntiAGE-Biom probiotic for 3 months, and the other group took a placebo (a pill that looked identical but had no active ingredients). Neither the participants nor the researchers knew who was getting the real probiotic until the study ended—this is called being “double-blind” and helps prevent bias.

The researchers measured several things at the beginning and end of the study: blood sugar control (using a test called HbA1c), body fat percentage, muscle mass, and insulin resistance (how well the body uses insulin). They also looked at whether results differed between men and women, and between people with different starting blood sugar levels.

This type of study design is strong because the placebo group helps show whether any improvements are actually from the probiotic or just from people feeling like they’re being treated.

The gut microbiome (the bacteria living in your digestive system) plays an important role in how your body processes food and controls blood sugar. By using a randomized, placebo-controlled design, researchers can determine whether the probiotic actually causes improvements or if improvements happen for other reasons. This careful approach is important because many supplements claim to help with diabetes, but few have solid scientific evidence.

Strengths: This study used a rigorous double-blind, placebo-controlled design, which is the gold standard for testing treatments. The researchers carefully measured multiple health markers. Weaknesses: The study was small (only 40 people), which limits how much we can trust the results. It was also conducted at just one medical center. The 3-month timeframe is relatively short for seeing major changes in diabetes control. Results that didn’t reach statistical significance (like the blood sugar improvement) suggest we can’t be confident those changes were real.

What the Results Show

The main goal was to see if the probiotic would lower blood sugar levels (measured by HbA1c). While the probiotic group showed a trend toward lower blood sugar, this improvement was not statistically significant, meaning it could have happened by chance. This was disappointing because blood sugar control is the primary concern for people with diabetes.

However, the probiotic did show more promising results for body composition. After 3 months, men taking the probiotic had a significant reduction in body fat percentage and an increase in skeletal muscle mass and lean mass in their trunk (the main part of the body). In women, the results were less clear. Additionally, in a subgroup of people who started with higher blood sugar levels (HbA1c ≥ 6.5%), the probiotic also helped reduce body fat percentage.

These body composition changes are meaningful because excess body fat, especially around the trunk, is linked to insulin resistance and poor diabetes control. Building muscle mass can also help improve how the body uses insulin.

The study also measured insulin resistance using a test called HOMA-IR, though the abstract doesn’t provide detailed results for this measure. The improvements in body composition—particularly the reduction in body fat and increase in muscle mass—suggest that the probiotic may help the body work more efficiently, even if it didn’t directly lower blood sugar in this short timeframe. These changes could potentially lead to better diabetes control over a longer period.

This research fits into a growing area of study about how gut bacteria affect diabetes. Previous research has suggested that probiotics might help with blood sugar control and weight management, but results have been mixed. This study is one of the first to specifically test the AntiAGE-Biom probiotic in people with type 2 diabetes. The finding that it improved body composition but not blood sugar is somewhat different from what some earlier studies suggested, indicating that probiotics may work differently than initially hoped.

This study has several important limitations. First, it was small—only 40 people—which means the results might not apply to larger populations. Second, it lasted only 3 months, which may not be long enough to see significant changes in blood sugar control. Third, the results were different between men and women, and we don’t fully understand why. Fourth, the study was conducted at only one medical center, so the results might not apply to different populations or geographic areas. Finally, the fact that blood sugar didn’t improve significantly raises questions about whether this probiotic is truly helpful for the main concern in diabetes management.

The Bottom Line

Based on this research, AntiAGE-Biom probiotic may help improve body composition in people with type 2 diabetes, particularly in men and those with higher starting blood sugar levels. However, it should NOT replace your current diabetes medications or treatment plan. If you’re interested in trying this probiotic, discuss it with your doctor first. The evidence is still preliminary (confidence level: moderate for body composition improvements, low for blood sugar control), so more research is needed.

This research is most relevant to people with type 2 diabetes who are looking for additional ways to improve their body composition alongside their regular treatment. Men may see more benefit than women based on this study. People with higher blood sugar levels might also benefit more. However, anyone considering this probiotic should talk to their doctor first, especially if they take medications or have other health conditions. This is not a replacement for standard diabetes care.

In this study, changes in body composition became visible after 3 months. However, improvements in blood sugar control typically take longer to develop. If you were to try this probiotic, you might expect to see changes in body composition within 2-3 months, but you should continue monitoring your blood sugar regularly with your doctor to see if there are longer-term benefits.

Want to Apply This Research?

  • If using a diabetes management app, track weekly body weight and monthly body composition measurements (if available through your doctor or a scale that measures body fat percentage). Also continue regular blood sugar monitoring as prescribed by your doctor, noting any patterns over time.
  • Users could log daily probiotic intake in their app and correlate it with weekly measurements of body weight and waist circumference. This personal tracking helps identify whether the probiotic is working for your individual body, since results varied between people in the study.
  • Set up monthly check-ins to review trends in body composition and blood sugar levels. Create reminders to take the probiotic consistently (if your doctor recommends it) and to measure progress. Share these trends with your healthcare provider during regular appointments to determine if the probiotic is helping your overall diabetes management.

This research describes a preliminary study on a specific probiotic supplement for type 2 diabetes. The findings are promising but not yet conclusive, and this probiotic should not replace your prescribed diabetes medications or treatment plan. Always consult with your doctor or diabetes care team before starting any new supplement, as probiotics can interact with medications and may not be appropriate for everyone. This summary is for educational purposes only and should not be considered medical advice. Individual results may vary, and what works for one person may not work for another.