Researchers tested a new dietary supplement called Dibifree made from plant-based ingredients on 40 people with type 2 diabetes. Over seven months, people who took Dibifree alongside their regular diabetes treatment saw improvements in their blood sugar levels and body fat compared to those taking a placebo. The supplement appears to work by helping the body produce more of a hormone that controls blood sugar and by reducing inflammation. While these results are promising, more research with larger groups of people is needed before doctors might recommend it widely.

The Quick Take

  • What they studied: Whether a plant-based dietary supplement called Dibifree could help people with type 2 diabetes better control their blood sugar levels and reduce body fat when used alongside their regular diabetes medications.
  • Who participated: 40 adults with type 2 diabetes participated in this study. They were randomly assigned to receive either Dibifree or a placebo (fake supplement) for three months, then switched groups after a one-month break.
  • Key finding: People taking Dibifree showed significant improvements in their HbA1c (a measure of average blood sugar over three months), fasting blood sugar, and blood sugar after meals compared to placebo. They also lost body fat. These improvements stayed even after they stopped taking the supplement and then took it again.
  • What it means for you: If you have type 2 diabetes, Dibifree may help improve your blood sugar control when used with your regular medications. However, this is early-stage research with a small group, so talk to your doctor before trying it. It’s not a replacement for your current diabetes treatment.

The Research Details

This was a randomized controlled trial, which is one of the strongest types of research studies. Forty people with type 2 diabetes were randomly divided into two groups. One group received Dibifree (a 15-gram daily dose of a plant-based mixture) while the other received a placebo (a fake supplement that looked identical). Neither the participants nor the researchers knew who was getting the real supplement—this is called “double-blind” and helps prevent bias.

The study lasted seven months total. Each group took their assigned supplement for three months, then everyone stopped for one month (called a “wash-out” period). After that, the groups switched: people who had taken placebo now took Dibifree, and vice versa. This crossover design is powerful because each person essentially serves as their own comparison.

Researchers measured blood sugar control using three tests: fasting blood sugar (measured after not eating overnight), blood sugar after meals, and HbA1c (which shows average blood sugar over three months). They also measured body fat percentage and conducted laboratory tests to understand how the supplement worked at the cellular level.

The crossover design is particularly valuable because it reduces the impact of individual differences between people—each person’s results are compared to their own baseline rather than to others. The double-blind aspect prevents expectations from influencing results. By measuring multiple aspects of blood sugar control and conducting laboratory studies, the researchers could understand not just whether the supplement worked, but potentially how it worked.

Strengths of this study include its randomized, double-blind, placebo-controlled design and the crossover structure. The researchers also conducted detailed laboratory studies to understand the mechanisms. However, the sample size of 40 people is relatively small, which means results should be confirmed in larger studies. The study was published in a peer-reviewed journal, meaning other experts reviewed the work before publication. The fact that benefits persisted after stopping and restarting the supplement strengthens confidence in the findings.

What the Results Show

People taking Dibifree showed meaningful improvements in all three measures of blood sugar control. Their HbA1c levels decreased significantly compared to placebo, meaning their average blood sugar over three months improved. Fasting blood sugar (measured in the morning before eating) also dropped noticeably. Additionally, blood sugar levels measured after meals were lower in the Dibifree group.

One particularly interesting finding was that these improvements persisted even after people stopped taking the supplement for one month, and the benefits returned when they started taking it again. This suggests the supplement may have created lasting changes in how the body handles blood sugar, rather than just temporarily masking the problem.

Beyond blood sugar, people taking Dibifree also lost body fat percentage compared to the placebo group. This is important because excess body fat, especially around the organs, makes diabetes harder to control.

The laboratory studies revealed that Dibifree appears to work through multiple pathways: it increased production of a hormone called GLP-1 that helps control blood sugar, it blocked enzymes that break down carbohydrates too quickly, and it reduced harmful compounds called AGEs that form when blood sugar is high.

Laboratory tests showed that Dibifree reduced the formation of AGEs (advanced glycation end products), which are harmful compounds that form when blood sugar stays high. These compounds contribute to diabetes complications. The supplement also appeared to reduce fat cell formation and promoted a shift in immune cells toward a less inflammatory state, which is beneficial for people with diabetes since inflammation makes the condition worse.

This research builds on previous studies showing that certain plant compounds can help with blood sugar control. What makes this study novel is that it combines multiple plant-based ingredients into one supplement and tests it in people with diabetes, not just in laboratory settings. The mechanisms identified—particularly the enhancement of GLP-1 production—align with how some modern diabetes medications work, suggesting Dibifree may work through similar biological pathways.

The main limitation is the small sample size of 40 people, which means results need to be confirmed in larger studies before drawing firm conclusions. The study lasted seven months, which is relatively short for evaluating long-term effects. The research doesn’t tell us how Dibifree compares to standard diabetes medications or whether it works equally well for all types of people with type 2 diabetes. Additionally, we don’t know the long-term safety profile or whether benefits continue beyond the study period. The study was conducted in a controlled research setting, which may not reflect real-world conditions where people might not take supplements consistently.

The Bottom Line

Based on this research, Dibifree shows promise as an add-on therapy (meaning used alongside regular diabetes medications, not instead of them) for improving blood sugar control and reducing body fat in people with type 2 diabetes. However, confidence in these recommendations is moderate because the study is small and needs replication. If you have type 2 diabetes, discuss with your doctor whether Dibifree might be appropriate for you. Do not stop or reduce your current diabetes medications without medical guidance. Larger, longer studies are needed before Dibifree could be widely recommended.

This research is most relevant to adults with type 2 diabetes who are looking for additional ways to improve their blood sugar control alongside their current treatment. It may be of particular interest to those who prefer plant-based approaches or who want to reduce their reliance on medications (though always under doctor supervision). People with type 1 diabetes, pregnant women, or those with severe kidney or liver disease should not consider this without specific medical guidance. Anyone taking blood sugar-lowering medications should consult their doctor before adding any supplement, as combinations could cause blood sugar to drop too low.

Based on this study, improvements in blood sugar control appeared within three months of taking Dibifree. Body fat reduction also occurred within this timeframe. However, individual results vary, and some people may see benefits sooner or later than others. It typically takes several weeks for the body to adjust to any new supplement, so patience is important. The fact that benefits persisted after stopping suggests that positive changes may continue even after discontinuing use, though this needs further study.

Want to Apply This Research?

  • Track your fasting blood sugar (measured each morning before eating) and record it daily in the app. If you have a home HbA1c monitor or regular lab tests, log those results monthly. This will help you see patterns and whether the supplement is working for you personally.
  • If you decide to try Dibifree with your doctor’s approval, set a daily reminder in the app to take your 15-gram dose at the same time each day (consistency matters). Also log what you eat and your blood sugar readings to identify which foods work best with the supplement.
  • Create a monthly dashboard showing your average fasting blood sugar, any HbA1c test results, body weight, and how you’re feeling. Compare these metrics month-to-month to track whether the supplement is providing benefits for you. Share this data with your doctor at regular check-ups to ensure the supplement is working well with your other medications.

This research describes a dietary supplement study and should not be interpreted as medical advice. Dibifree is not approved by the FDA and is not a replacement for prescribed diabetes medications. If you have type 2 diabetes, consult your doctor or healthcare provider before starting any new supplement, as it may interact with your current medications or affect your blood sugar levels. Do not change, reduce, or stop your diabetes medications without medical supervision. This summary is for educational purposes only and based on a single study with a small sample size. Larger, longer studies are needed to confirm these findings before widespread medical recommendations can be made.